Assessment of insulin like growth factor-1 and IGF binding protein in healthy Indian girls from Delhi and their correlation with age, pubertal status, obesity and thyroid hormonal status

Authors: R.K. Marwaha

Published: JPEM 2017; 2017. 30; 739-747.

Link: https://pubmed.ncbi.nlm.nih.gov/28672739/

Conclusions: This study for the first-time established age wise levels of insulin growth factors (IGF-1) and insulin growth factors binding proteins (IGFBP-3) which are important for the management of children with short stature. No significant impact of age on IGF-1 and IGFBP-3 was observed in pre-pubertal girls. A sudden marked increase at 11 years followed by a gradual rise in growth factors till 16 years was indicative of pubertal initiation and maturation. Subclinical hypothyroidism did not influence growth factors in girls.